Patient Relapse Time After Auto-HCT in Chemosensitive DLBCL Does Not Appear to Influence PFS
The data reinforce the need for direct comparison of CAR-T and autologous transplantation.
Hematologic Cancers
Dual-Targeting CAR-T Appears Active in R/R DLBCL
The Alexander study was designed to test if dual-targeting of CD19 and CD22 would reduce the likelihood of antigen escape.
Deep and Durable Responses to Double Anti-BCMA, Single-Domain Antibody CAR-T Therapies Seen in RRMM
CAR-T therapy containing 2 anti-BCMA single-domain antibodies resulted in high response and PFS rates, according to phase 1b results.
Allogeneic CAR-T Therapies Appear Safe in LBCL/FL
The “universal” products have the potential to address the challenges of autologous CAR-T.
Anti-BCMA CAR-T Deemed Effective in Heavily Pretreated, Refractory Multiple Myeloma
Anti-BCMA CAR T-cell therapy idecabtagene vicleucel demonstrated promising efficacy among patients with heavily pretreated and refractory MM.
Investigating CAR-T Efficacy Limitations in Chronic Lymphocytic Leukemia
Efficacy limitations of CAR-T therapy in CLL may not be due to defects in the CAR-T product, but rather, to characteristics of the tumor cells.
ETV6 Sequencing Important Among Patients With Inherited Thrombocytopenia, Malignancy
It may be important to sequence ETV6in patients with inherited thrombocytopenia or malignancy and to schedule regular follow-ups to check for secondary cancers.
Preliminary Evidence Supports Benefit of Urinary-Derived hCG in Acute GVHD
In this phase I clinical trial, 2 different cohorts of patients with acute GVHD received subcutaneous injections of uhCG along with standard-of-care treatment.
Emapalumab Effective for Pediatric Primary Hemophagocytic Lymphohistiocytosis
Emapalumab as a target therapy may benefit children with primary HLH.
Study Links DLBCL and CLL Incidence to Race and Ethnicity, Urban Status
The incidence of DLBCL among Hispanic individuals and CLL among non-Hispanic black individuals was associated with urban status.
Next post in Chronic Lymphocytic Leukemia
