Leukemia

Four specific mutations in SH2 domain seen in T-cell large granular lymphocytic leukemia.

The first study to demonstrate conclusively that adherence to oral mercaptopurine influences risk of relapse in children with acute lymphoblastic leukemia (ALL) also found an ethnic difference in relapse risk that differed by level of adherence.

Using this sequence-based assay, researchers will be able to investigate the human TET2, CBL, KRAS and RUNX1 genes, which are known to be associated with developmental defects, disease progression, and residual disease in a variety of leukemias and myeloid malignancies.

Lower mortality, improved remission and event-free survival rates, lower relapse rates.

For patients with chronic lymphocytic leukemia (CLL) and deletion of TP53, alemtuzumab plus methylprednisolone is a highly effective induction regimen

A subset of pediatric patients with acute lymphoblastic leukemia (ALL) who have precursor B-cell leukemia appear to have a better outcome with chemotherapy after failing remission-induction therapy.

The first Clinical Practice Guidelines in Oncology for the treatment of Acute Lymphoblastic Leukemia have been produced by the NCCN.