Scemblix Approved for Ph+ Chronic Myeloid Leukemia in Chronic Phase
Asciminib inhibits the ABL1 kinase activity of the BCRABL1 fusion protein, by binding to the ABL myristoyl pocket.
Leukemia
Algorithm Assesses Risk of Major Adverse Cardiovascular Events in TKI-Treated CML
Researchers sought to determine the accuracy of established tools in predicting the risk of cardiovascular events in patients with CML receiving TKIs.
HSCT After COVID-19 Appears Safe, but Most Patients Lose SARS-CoV-2 Antibodies
All patients achieved engraftment, and none developed complications associated with COVID-19.
Diagnosis and Management of Differentiation Syndrome in Patients With Acute Myeloid Leukemia
Differentiation syndrome is a potentially severe complication in AML, although prompt management is usually effective and rarely requires cessation of targeted therapy.
Genomic Markers May Predict Clinical Outcomes in Patients With B-Cell Acute Lymphoblastic Leukemia
Researchers sought to determine whether genomic evaluation in patients with BCR-ABL1 negative B-ALL may improve risk assessments.
Trial to Compare Diets in Patients With Leukemia or MDS and Prolonged Neutropenia
The trial’s primary objective is to compare the incidence of major infections.
Breast, Prostate Cancer Common in Patients With COVID-19 and Cancer History
For patients hospitalized with COVID-19, prostate cancer was the most common cancer type across all databases.
Poor Prognosis Seen for Patients With B-Cell Acute Lymphoblastic Leukemia Progression After CAR-T Therapy
Researchers sought to determine whether patients with B-ALL who progress after CAR-T therapy would have a poor prognosis.
Tecartus Approved for Relapsed/Refractory B-Cell Precursor Acute Lymphoblastic Leukemia
The approval was based on data from the phase 1/2 ZUMA-3 trial.
Racial/Ethnic Disparities ID’d in Childhood Cancer Survival
Survival disparities decreased after adjustment for health insurance and area-level socioeconomic status.
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