Study of Combination Ibrutinib and Venetoclax in Mantle Cell Lymphoma
The study includes patients with relapsed/refractory and treatment-naïve mantle cell lymphoma.
The study includes patients with relapsed/refractory and treatment-naïve mantle cell lymphoma.
Researchers are seeking to compare the efficacy and safety of the combination of ibrutinib and venetoclax compared with ibrutinib and placebo in patients with mantle cell lymphoma.
The trial will compare LOXO-305 to investigator’s choice of ibrutinib, acalabrutinib, or zanubrutinib.
Initial treatment of mantle cell lymphoma with lenalidomide and rituximab may result in significant complete response rates and durable lengths of remission.
A retrospective analysis highlights the reasons for discontinuation of ibrutinib among patients with mantle cell lymphoma.
In a phase 2 trial, obinutuzumab added to induction therapy showed promising activity and tolerability for transplant-eligible mantle cell lymphoma.