Comparable Outcomes With and Without Neoadjuvant Therapy in High-Risk Melanoma
Patients with high-risk, stage III melanoma have similar outcomes whether they undergo surgery upfront or receive immunotherapy prior to surgery, a study suggests.
Diagnosis & Disease Information
Personalized ctDNA Monitoring Can Predict Outcomes in Advanced Melanoma
Personalized ctDNA monitoring can predict outcomes during and after treatment in patients with advanced melanoma, a study suggests.
Certain Antibiotics May Reduce the Efficacy of Certain ICIs in Cancer Patients
A new study suggests that fluoroquinolones — but not other antibiotics — may reduce the efficacy of certain ICIs in certain cancers.
Periadjuvant Pembrolizumab Improves EFS in Resectable Melanoma
Periadjuvant pembrolizumab may improve outcomes over adjuvant pembrolizumab alone in patients with resectable stage III-IV melanoma, a phase 2 study suggests.
Nivolumab sBLA Accepted for Patients With Completely Resected Stage IIB, IIC Melanoma
The application is supported by data from the phase 3 CheckMate76K trial.
Methotrexate May Be Linked to Increased Risk of Skin Cancer
Methotrexate use may be associated with an increased risk of skin cancer, but more research is needed.
Cancer Vaccine Plus Pembrolizumab Granted Breakthrough Designation
The FDA has granted breakthrough therapy designation to mRNA-4157/V940 in combination with pembrolizumab to treat melanoma.
Nivolumab Plus Relatlimab Yields Durable Responses After Progression of Advanced Melanoma
Nivolumab plus relatlimab can produce durable responses in patients with advanced melanoma whose disease progressed on anti-PD-1/PD-L1 regimens.
Cancer Clinical Trials Do Not Include Leptomeningeal Disease-Specific Endpoints
Phase 3 trials for metastatic breast cancer, lung cancer, and melanoma do not include leptomeningeal disease-specific endpoints.
AYAs With Melanoma Fare Worse Than Older Adults
Survival outcomes of advanced melanoma are worse for AYAs than for older adults, a study suggests.
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