New Treatments for Advanced Melanoma
The introduction of ipilimumab and vemurafenib may be the beginning of the identification of melanoma treatment options that improve survival outcomes based upon patient immune response.
Melanoma
Melanoma Incidence Increasing Among Young Adults
From 1970 to 2009, there was an increase in the incidence of melanoma among young adults, particularly females.
Inhibition of Immune Pathway May Trigger Melanoma Growth
Colocalization of immune inhibitory B7-H1 and tumor-infiltrating lymphocytes seen in melanocytes.
Ipilimumab Has Activity in Advanced Melanoma, Brain Metastases
Ipilimumab has activity in some patients with advanced melanoma and brain metastases — particularly when metastases are small and asymptomatic — with no unexpected toxic effects, investigators concluded in the Lancet Oncology online March 26.
Cutaneous Toxicity Following Vemurafenib Therapy Suggests BRAF Inhibition
Three patients with BRAF-positive stage IV melanoma who had cutaneous toxic effects following vemurafenib administration—including sequela not previously reported—suggests BRAF inhibition alone may be sufficient to induce such changes, a study published in Archives of Dermatology online March 19 has found.
20-Year Survival Rates for Thin Melanoma Now Known
Outlook for patients with thin melanomas is positive say the authors of a study recently published in the Journal of Clinical Oncology.
Abscopal Effect Bolsters Combination Therapy for Melanoma Patients
Patients with advanced stage melanoma may have promising combination therapy.
Mechanism of BRAF Inhibitor Resistance Elucidated
Alternative clinical strategies have the potential to overcome the underlying acquired B-RAF inhibitor resistance that can hamper long-term therapeutic success in melanoma.
Sunitinib Shows Promise in Metastatic Melanoma Patients
Sunitinib, a tyrosine kinase inhibitor, has been approved by the FDA for the treatment of kidney cancer and stromal gastrointestinal cancer, but its effectiveness in melanoma was unknown until this study.
Activities, Smoking Affect Lymph Node Involvement in Melanoma
Several factors, including sporting activity, physical workload, and smoking habits, affect the sonomorphologic characteristics of peripheral lymph nodes (LNs) in patients with a history of invasive cutaneous melanoma.
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