From 1970 to 2009, there was an increase in the incidence of melanoma among young adults, particularly females.
Colocalization of immune inhibitory B7-H1 and tumor-infiltrating lymphocytes seen in melanocytes.
Ipilimumab has activity in some patients with advanced melanoma and brain metastases — particularly when metastases are small and asymptomatic — with no unexpected toxic effects, investigators concluded in the Lancet Oncology online March 26.
Three patients with BRAF-positive stage IV melanoma who had cutaneous toxic effects following vemurafenib administration—including sequela not previously reported—suggests BRAF inhibition alone may be sufficient to induce such changes, a study published in Archives of Dermatology online March 19 has found.
Outlook for patients with thin melanomas is positive say the authors of a study recently published in the Journal of Clinical Oncology.
Patients with advanced stage melanoma may have promising combination therapy.
Sunitinib, a tyrosine kinase inhibitor, has been approved by the FDA for the treatment of kidney cancer and stromal gastrointestinal cancer, but its effectiveness in melanoma was unknown until this study.
Several factors, including sporting activity, physical workload, and smoking habits, affect the sonomorphologic characteristics of peripheral lymph nodes (LNs) in patients with a history of invasive cutaneous melanoma.