TP53 Mutations Present in HPV-Negative Vulvar Cancer
In a whole-exome analysis, the most common mutations occurred in TP53, and mutations in other known cancer-associated genes were identified in women with HPV-negative vulvar cancer.
Ovarian Cancer
Uterus-Preserving Surgery May Be an Option for Ovarian Cancer Subtype
Women with Stage I primary mucinous epithelial ovarian carcinoma who underwent uterus-preserving surgery did not have worse survival, a retrospective study found.
Neoadjuvant Chemotherapy Increases Immunogenicity of High-Grade Serous Ovarian Cancer
This study sought to address outstanding questions regarding tumor heterogeneity in the setting of HGSOC, including its relationship with treatment response.
Birth Rates After ART Not Significantly Different Among Female Cancer Survivors, Siblings
The researchers found that patients who received pelvic radiation had a decreased chance of live birth.
KEYNOTE-100: Pembrolizumab Had Modest Activity in Recurrent Advanced Ovarian Cancer
Analysis of biomarkers to predict response to pembrolizumab are ongoing.
Olaparib/Cediranib Combination Is Not Superior to Standard of Care in Recurrent Ovarian Cancer
Overall survival data are not currently mature. However, at the time of this analysis no difference in overall survival was observed between the 3 treatment arms.
Secondary Cytoreductive Surgery Extended PFS in Recurrent Ovarian Cancer
A longer treatment-free survival interval associated with surgery may contribute to overall survival.
Tyrer-Cuzick Breast Cancer Model Well-Calibrated Among Most Races/Ethnicities
The TC model uses various parameters to predict risk such as genetic risk and nonfamilial factors including personal, hormonal, and lifestyle characteristics.
CA-125 as a Biomarker of Response to Immune Checkpoint Therapy in Ovarian Cancer
Although ICI therapy has been shown to have limited efficacy in ovarian cancer (OC), some patients with OC do achieve long-term clinical benefit from this approach.
Later Bedtime May Be Associated With Higher Levels of Pain in Ovarian Cancer Survivors
An analysis utilized the baseline characteristics of patients with pretreated ovarian cancer enrolled in a phase 3 trial to evaluate lifestyle interventions.
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