Less Postoperative Chemotherapy for Pediatric Hepatoblastoma Has No Effect on Disease Control
Fewer chemotherapy cycles could decrease long-term morbidity for certain patients.
Pediatric Cancer
Potential Unintended Consequences of the “Right to Try” Act on the Delivery of Palliative Care to Children With Cancer
Will “cure-seeking behavior” for terminally ill children with cancer interfere with the integrated delivery of palliative care?
“Real-World” Hospitalization Data on Patients Receiving CAR-T Cell Therapy
An investigation of a large performance improvement clinical database revealed that most individuals receiving CAR-T have diagnoses of ALL or large B-cell lymphoma.
Reducing the Reliance on Opioids for Cancer Pain: Is the Switch to Cannabis a Viable Option?
Articles discussing the use of cannabis as a substitute for opioids highlight the limitations of the existing scientific evidence in the field.
Cancer Death Rates Continue to Decline, but Socioeconomic Gaps Widen
The continuous decline in cancer deaths over the past 25 years was attributed to improvements in screening, treatment.
Should Widespread Early Detection Cancer Screening End?
Experts examined the role of population-based early detection cancer screening.
Checkpoint Inhibitors Boost Cancer Vaccine Research
Researchers are excited about the prospect to use vaccines in combination with checkpoint inhibitors to improve the body’s cancer-fighting ability.
Is Real-World Evidence a Complement to Randomized Clinical Trials?
Use of real-world data has the potential to accelerate drug and device approvals in rare diseases and advance precision medicine initiatives.
Gene-Delivery Method Generates Immune Checkpoint Antibodies In Vivo
In mice, DNA-encoded plasmids generated sufficient in vivo expression of immune checkpoint antibody CTLA-4; DMabs may one day rival traditional mAbs.
Preexisting Immunity to CRISPR-Cas9: A Problem for Gene Editing in Cancer?
Evidence is building to show that most people have preexisting immunity to CRISPR-based therapies. In cancer, however, it’s unclear how much that matters.
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