The FDA Approval Process Needs Refinement, Not a Total Overhaul
Even though overall drug development times have not changed, questions about the clinical benefit of the drugs that have been approved through expedited pathways are being raised.
Sarcoma
How Durable Are Responses to Targeted Therapies Across Single-Arm Cancer Trials?
Drugs approved based on changes to surrogate biomarker levels may be subject to measurement bias, according to investigators.
Reporting Mechanisms for Conflict of Interest Disclosures in Medicine Need Standardization
ASCO officials examined the discrepancies in financial disclosures across platforms and call for a simplified system.
Public Insurance Tied to Lower Cancer Survival in Young Patients
Findings seen among patients <40 years with bone or soft tissue sarcomas, regardless of disease stage.
Armed “Bionic” T Cells Show Preclinical Cytotoxic Activity — No CAR Required
A “bionic” T cell that is armed with a bispecific antibody but lacks a chimeric antigen receptor showed cytotoxic activity in cancer cell lines.
Popular Genetic Tests Miss Many Cancer-Associated Genetic Variants, Particularly in Ethnic Minorities
The chance of missing a disease-causing variant can be as high as 100% across some groups.
When Patient-Reported Outcomes Could Pose Risks
During a recent conference on quality of life in patients with cancer, FDA-affiliated researchers debunked a notion about biases — but raised some concerns about PROs.
Next-Gen CAR Platform Touts Potential of 1-Day Manufacturing
A single-day, cGMP-compliant manufacturing process to make a cryopreserved drug product, if successful, could dramatically reduce patient wait times.
How to Help Patients With Cancer Find Trustworthy Information Online
Patients may find misinformation on websites or social media forums, but doctors can help by recommending reliable sources.
Gender Bias in Oncology: Q&A With Dr Narjust Duma
Women are less likely to be introduced by their professional title and most likely to be introduced by first name.
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