Fragmentation Pattern of Cell-Free DNA Can Reveal Cancer, Even at Early Stages
Machine learning algorithm detected 7 types of cancer in liquid biopsy and identified tissue of disease origin.
Sarcoma
Solving the Obesity Paradox in Oncology
One potentially revolutionary hypothesis relates to the evolutionary processes involved in oncogenesis.
Clinical Trial Assesses Combination Chemotherapy With or Without Temsirolimus for Intermediate-Risk Rhabdomyosarcoma
Combination chemotherapy and temsirolimus may stop the growth of tumor cells by blocking some of the enzymes needed for cell growth.
Multidisciplinary Genetic Tumor Boards: Critical for Interpreting Tumor-Only Sequencing Results
One approach for improving recommendations based on tumor-only sequencing is use of a multidisciplinary genomic tumor board, in which researchers from a variety of backgrounds weigh in on the best way to interpret test results.
The Revival of a Forgotten Cancer Gene Therapy With Off-the-Shelf Potential
A universal cancer gene therapy from the early 2000s is headed into phase 2 trials, in light of renewed interest and outlier patients who are still alive at 10 years later.
The Accelerated Rise and Fall of Olaratumab in Sarcoma
Investigators from the ANNOUNCE trial suggested potential explanations for why there were such different outcomes across 2 of its trials.
Advanced Soft Tissue Sarcomas: Dox + Olaratumab vs. Dox + PBO
Alexander Spira MD, PhD, discusses his research at the ASCO 2019 meeting.
In-House or Centralized Testing? Debating Whether Genomic Sequencing Is Best Conducted at Home
Genomic analysis of tumors and tests measuring certain biomarkers can be done in-house or sent out. What are the costs and benefits of each approach?
Kaposi Sarcoma Treatment Gets Breakthrough Therapy Designation
The FDA has granted Breakthrough Therapy designation to Pomalyst (pomalidomide; Celgene) for the treatment of patients with Kaposi sarcoma.
What Do Surrogate End Points Actually Predict?
As understanding of cancer improves, drug development could become accelerated, necessitating a means for determining whether a drug is actually effective.
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