Tapping Into the Therapeutic Expertise of High-Volume Cancer Centers
Researchers examine how patient outcomes could be affected if patients were to receive systemic drug treatment at dedicated cancer centers versus at community health systems.
Skin Cancer
TKI Combination vs Monotherapy for Advanced Melanoma and the Risk for CV Adverse Events
A meta-analysis sought to determine if survival is improved with dual targeting of the MAPK pathway with BRAF and MEK inhibitors vs BRAF inhibition alone in patients with advanced melanoma.
Personalized Cancer Vaccine NEO-PV-01 Shows Promise in 3 Types of Advanced Cancer
Early results from a clinical trial of personalized cancer vaccine NEO-PV-01 in 3 types of advanced cancer have shown promise and no significant toxicity issues.
Bempegaldesleukin Combo Regimen Gets Breakthrough Status for Untreated Advanced Melanoma
The Food and Drug Administration (FDA) has granted Breakthrough Therapy designation to bempegaldesleukin (NKTR-214; Nektar Therapeutics and Bristol-Myers Squibb) in combination with nivolumab (Opdivo; Bristol-Myers Squibb) for the treatment of patients with previously untreated unresectable or metastatic melanoma.
Dietary Vitamin A Intake Tied to Reduced Risk for Squamous Cell Carcinoma
Cutaneous SCC risk reduced for highest versus lowest quintile of vitamin A, retinol, some carotenoids.
New Research on Anti–PD-1 Drugs Helps Fill Gaps in Knowledge on Immunotherapies in Melanoma
Oncologists lacking long-term data now have more information on relapse rates and the role of obesity in treatment success.
Determining Risk Factors for Recurrence of Primary Localized Cutaneous Melanoma
Researchers sought to determine the risk of disease recurrence in patients with localized melanoma at high risk of disease metastasis.
Time Between Initial Surgery and First Distant Recurrence Not Predictive of Response to Systemic Therapy in Metastatic Melanoma
With the exception of those enrolled in a clinical trial, all patients in this study received systemic monotherapy as first-line treatment of metastatic melanoma.
Calculated Tumor Area Has Prognostic Value for Melanoma
Calculated tumor area is a novel, microscopic feature and a two-dimensional surrogate
for tumor size.
Machine Versus Physician: Assigning Diagnoses to Pigmented Skin Lesions
Approximately one half of all biopsied/excised lesions from patients who have sun-damaged skin are nonmelanocytic.
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