No Solid Evidence to Support GEP Testing in Thin Melanoma
Most studies that have looked at 31-GEP testing in melanoma have been retrospective or prospective, and did not involve a comparator group.
Skin Cancer
Neoadjuvant Nivolumab Appears Promising in Merkel Cell Carcinoma
A small phase 1/2 study shows high pCR rates.
A New Look at the Dose-Response Relationship in Phase 1 Oncology Trials
The new generation of cancer drugs behave quite differently than cytotoxic therapies, and that may mean phase 1 trials need to be updated.
Exposure to Antibiotics Associated With Survival Detriment in Patients With Advanced Melanoma Treated With ICIs
Previous studies have shown an association between gut microbiome diversity and response to immune checkpoint inhibitor therapy.
Continuous Dosing of BRAF/MEK Inhibition Superior to Intermittent Dosing in Melanoma
Continuous dosing of dabrafenib-trametinib resulted in prolonged PFS compared with intermittent dosing in advanced BRAF-mutated advanced melanoma.
Atezolizumab Plus BRAF/MEK Inhibition Prolonged PFS in Melanoma
Atezolizumab plus cobimetinib and vemurafenib prolonged PFS in unresectable or metastatic melanoma compared with placebo and BRAF/MEK inhibition in the phase 3 IMspire150 trial.
Keratinocyte Carcinoma Risk Factors in Allogeneic Hematopoietic Cell Transplant Recipients
Although allogeneic HCT is associated with increased risk for keratinocyte carcinoma, the magnitude of risk linked to certain patient characteristics is still unknown.
Thyroid Dysfunction During Anti–PD‐1 Immunotherapy Linked to Better Survival Outcomes
There was no increase in survival linked to acquired subclinical thyroid dysfunction or preexisting thyroid dysfunction, however.
Model Could Help Identify Who May Respond to Checkpoint Inhibition in Melanoma
Imaging radiomics and blood markers could differentiate pseudoprogression.
NBUVB Phototherapy May Not Increase Skin Cancer Risk in Patients With Vitiligo
Many patients with vitiligo undergo multiple courses of phototherapy, which may raise concerns about their risk of photocarcinogenesis.
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