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Trihexyphenidyl Elixir
Parkinsonism
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Drug Name:

Trihexyphenidyl Elixir Rx

Generic Name and Formulations:
Trihexyphenidyl HCl 2mg/5mL; lime-mint flavor; contains alcohol.

Company:
Pfizer Inc.

Therapeutic Use:

Indications for Trihexyphenidyl Elixir:

Adjunct in Parkinsonism. Drug-induced extrapyramidal symptoms (EPS).

Adult:

Take with food. Give in 3–4 divided doses. Parkinsonism: 1mg on day 1, may increase by 2mg every 3–5 days; usual max 6–15mg/day. Concomitant levodopa: 3–6mg/day and reduce levodopa dose. EPS: 1mg on day 1; range 5–15mg/day.

Children:

Not recommended.

Contraindications:

Tardive dyskinesia. Narrow-angle glaucoma.

Warnings/Precautions:

Cardiovascular, renal, or hepatic disorders. Hypertension. Psychosis. GI or GU obstruction. Exposure to extreme heat. Monitor intraocular pressure. Avoid abrupt cessation. Nursing mothers.

See Also:

Trihexyphenidyl Tabs

Pharmacological Class:

Anticholinergic.

Interactions:

Potentiates CNS depression with alcohol, CNS depressants. Antagonizes psychotropics. Additive anticholinergic effects with MAOIs. Paralytic ileus with phenothiazines, tricyclic antidepressants.

Adverse Reactions:

Anticholinergic and antihistaminic effects, confusion, anhidrosis, excitement, nausea, vomiting, angle-closure glaucoma, hallucinations, neuroleptic malignant syndrome, heat stroke, drowsiness.

Note:

Formerly known under the brand name Artane.

How Supplied:

Contact supplier.


Data provided by MPR.

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