Risk Factors for OAB and UI

 RISK FACTORS FOR OVERACTIVE BLADDER AND URINARY INCONTINENCE 
  Men Women
Age Prevalence of OAB with urge incontinence increased with age from 0.3% to 8.9% in men, with a marked increase after 64yrs of age. In men 65yrs of age and older, the prevalence increased to 8.2% (65–74yrs) and 10.2% (≥75yrs) [NOBLE study]. Prevalence of OAB with urge incontinence increased with age from 2% (18–24yrs) to 19.1% (65–74yrs) in women, with a marked increase after 44yrs of age [NOBLE study].
Chronic medical
conditions
MS, spinal cord injury, diabetes, Parkinson’s disease, stroke, dementia, impaired mobility, UTIs, smoking and obesity may cause bladder symptoms. Same for women.
Medications Diuretics, antidepressants, alpha-agonists, beta-antagonists, sedatives, anti-cholinergics, and analgesics can all cause urinary tract symptoms. Same for women.
Menopause and
estrogen
depletion
N/A Menopause has been associated with a decrease in urethralmucosa vascularity and thickness, as a result of diminished estrogen production.
Pelvic surgery Incontinence has been seen in men following surgical treatment for prostate cancer. Hysterectomy may increase a woman’s risk of incontinence.
Pregnancy
and childbirth
N/A Pregnancy and vaginal childbirth increase the risk of incontinence.
Post-childbirth incontinence has been associated with the use of forceps, vacuum extraction, episiotomy, and pudendal anesthesia.
Prostate-related
conditions
BPH, and prostatic obstruction secondary to BPH. Prostate cancer may also cause symptoms. N/A
Race The prevalence of OAB is 33.3% in African American (AA) men, 28% in Hispanic, 27% in Asian, and 26.3% in white men (EpiLUTS study). Similar trends were seen from the OAB-POLL study, with the highest prevalence in AA men (20.2%) compared to Hispanic (18.1%) or white (14.6%) men. The prevalence of OAB is 45.9% in AA women, 43.4% in white, 42% in Hispanic, and 26.6% in Asian women (EpiLUTS study). Data from the OAB-POLL study showed a prevalence of 32.6% in AA women compared to 29.4% in white and 29% in Hispanic women. NHANES data on UI supports that AA women report the highest prevalence of urge-UI (11%) over white (7.5%) and Mexican-American (7.5%) women.
NOTES

Key: AA = African-American; MS = multiple sclerosis; NOBLE = National Overactive Bladder Evaluation; OAB = overactive bladder; UI = urinary incontinence; UTIs = urinary tract infections

REFERENCES

1) Milsom I, Stewart W, Thuroff J. The Prevalence of Overactive Bladder. American Journal of Managed Care. 2000 Jul; 6 (11 suppl) S565-73.

2) Newman DK. Managing and Treating Urinary Incontinence. Baltimore, MD: Health Professions Press; 2002.

3) Reynolds WS, Fowke J, Dmochowski R. The Burden of Overactive Bladder on US Public Health; Curr Bladder Dysfunct Rep. 2016 Mar; 11(1): 8-13.

4) Stewart WF, Van Rooyen JB, Cundiff GW, et al. Prevalence and Burden of Overactive Bladder in US. World J Urol. (2003) 20:327-336.

(Rev. 12/2018)

This article originally appeared on MPR