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FDA Guidance: Expansion Cohort Trials Expected to Modernize Oncology Trials

There is a push to create innovative adaptive trial designs that include more patients and, subsequently, more generalizable data.

Robotic Partial Nephrectomy Compared With Open, Laparoscopic Partial Nephrectomy

A meta-analysis compared outcomes between the use of partial nephrectomy using a robotic surgical approach and open or laparoscopic partial nephrectomy.

Clues from DNA Repair Mechanisms Could Drive Novel Therapeutic Strategies

Metabolites from the Krebs cycle were found to suppress the DNA-repair pathway required for the preservation of genomic integrity.

Bispecific Antibodies in Cancer

Interest in these bioengineered antibodies has been rekindled by the striking success seen in the treatment of some cancers with immunotherapies.

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