Urologic Cancers

Prostate Cancer Drug Resistance Mediated by Epigenetic Changes

Prostate Cancer Drug Resistance Mediated by Epigenetic Changes

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Epigenetic changes in the tumor microenvironment may explain why prostate cancer patients develop resistance to androgen signaling deprivation therapy.

Later-Line Treatments for Metastatic Urothelial Carcinoma of the Bladder

Later-Line Treatments for Metastatic Urothelial Carcinoma of the Bladder

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Researchers propose a treatment algorithm to clarify treatment options beyond the first line for metastatic urothelial carcinoma of the bladder.

Supply Shortages of Bacillus Calmette-Guérin Found to Spur Drug Rationing in Non-Muscle-Invasive Bladder Cancer

Supply Shortages of Bacillus Calmette-Guérin Found to Spur Drug Rationing in Non-Muscle-Invasive Bladder Cancer

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BCG shortages did not appear to influence the incidence of radical cystectomy, but evidence of drug rationing was revealed.

Study Zeroes in on Cause of Castration-Resistant Prostate Cancer

Study Zeroes in on Cause of Castration-Resistant Prostate Cancer

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Some prostate cancer cells lack androgen receptors, and they proliferate faster than those that express androgen receptors under androgen-deficient conditions.

Oncology Community Expresses Concern About Medicare Advantage Step-Therapy Policy

Oncology Community Expresses Concern About Medicare Advantage Step-Therapy Policy

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More than 90 medical societies have called on the US government to reverse a policy allowing step therapy under Medicare Advantage.

Stromal Cells Found to Act as Tumor Bodyguards in Bladder Cancer

Stromal Cells Found to Act as Tumor Bodyguards in Bladder Cancer

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Gene expression of a biomarker linked to malignancies, found in stromal cells surrounding a tumor — not the tumor cells themselves — appears to prevent the action of checkpoint blockade.

Neoadjuvant Chemotherapy Before Radical Cystectomy May Improve Outcomes in Bladder Cancer

Neoadjuvant Chemotherapy Before Radical Cystectomy May Improve Outcomes in Bladder Cancer

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Researchers assess the outcomes of 5517 patients with bladder cancer who underwent radical cystectomy with or without neoadjuvant radiotherapy or chemotherapy.

Neoadjuvant ddMVAC May Lead to Improved Treatment Response in Bladder Cancer

Neoadjuvant ddMVAC May Lead to Improved Treatment Response in Bladder Cancer

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Previous studies showed that ddMVAC is well tolerated, but how it compares with gemcitabine plus cisplatin in regard to cancer control and survival outcomes requires further investigation.

Adjuvant Sunitinib in Renal Cell Carcinoma May Increase Symptoms, Reduce Health Quality Scores

Adjuvant Sunitinib in Renal Cell Carcinoma May Increase Symptoms, Reduce Health Quality Scores

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When sunitinib was given as an adjuvant therapy in renal cell carcinoma, patients reported worse symptoms and lower health-related quality of life scores.

Stereotactic Body Radiation Therapy May Improve Localized Control in Oligometastatic RCC

Stereotactic Body Radiation Therapy May Improve Localized Control in Oligometastatic RCC

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Stereotactic body radiation therapy (SBRT) may be a safe and effective therapeutic option that couold provide localized control.

FDA Guidance: Expansion Cohort Trials Expected to Modernize Oncology Trials

FDA Guidance: Expansion Cohort Trials Expected to Modernize Oncology Trials

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There is a push to create innovative adaptive trial designs that include more patients and, subsequently, more generalizable data.

Heavy Alcohol Intake in Early Life May Significantly Increase Odds of High-Grade Prostate Cancer

Heavy Alcohol Intake in Early Life May Significantly Increase Odds of High-Grade Prostate Cancer

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Recent analyses suggest that lifetime intake and early-life alcohol use may significantly contribute to the development of high-grade prostate cancer.

Bispecific Antibodies in Cancer

Bispecific Antibodies in Cancer

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Interest in these bioengineered antibodies has been rekindled by the striking success seen in the treatment of some cancers with immunotherapies.

IL-23 Drives Castration-Resistant Prostate Cancer

IL-23 Drives Castration-Resistant Prostate Cancer

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A growing body of evidence points to infiltrating myeloid-derived suppressor cells as key players in tumor progression and acquired treatment resistance.

Immediate Instillation of Mitomycin C Post-TURBT May Benefit All Patients with Bladder Cancer

Immediate Instillation of Mitomycin C Post-TURBT May Benefit All Patients with Bladder Cancer

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A reanalysis suggested that an instillation of chemotherapy immediately after surgery may benefit all patients with non-muscle-invasive bladder cancer.

Approximately Two-Thirds of Patients With Stage IV Bladder Cancer Remain Untreated

Approximately Two-Thirds of Patients With Stage IV Bladder Cancer Remain Untreated

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Patients in the SEER-Medicare database with stage IV bladder cancer were found to be less likely to receive chemotherapy than similar cohorts in earlier studies.

SBRT Appears Effective for Oligometastatic Prostate Cancer

SBRT Appears Effective for Oligometastatic Prostate Cancer

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Stereotactic body radiation therapy achieves good local control of metastases in patients with recurrent prostate cancer following primary treatment.

Cognitive Functioning Affects the Ability of Patients With Advanced Cancer to Give Informed Consent

Cognitive Functioning Affects the Ability of Patients With Advanced Cancer to Give Informed Consent

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Approximately half of patients with advanced cancer who are enrolled in phase 1 clinical trials do not know the ultimate goal of the study.

Robot-Assisted Cystectomy May Lead to Good Surgical, Oncologic Outcomes in Bladder Cancer

Robot-Assisted Cystectomy May Lead to Good Surgical, Oncologic Outcomes in Bladder Cancer

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With the advent of minimally invasive surgery programs, robotic-assisted radical cystectomy is becoming a point of interest for bladder cancer.

Lower Costs of Pazopanib for Advanced RCC May Influence Drug Choice

Lower Costs of Pazopanib for Advanced RCC May Influence Drug Choice

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Any new study of pazopanib or sunitinib must be placed in perspective of the changing treatment landscape and the market entrance of new immunotherapies.

Factors Associated With Locoregional Recurrence in Muscle-Invasive Bladder Cancer

Factors Associated With Locoregional Recurrence in Muscle-Invasive Bladder Cancer

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A better understanding of the factors associated with locoregional recurrence and focused adjuvant therapeutic strategies may lead to enhanced oncologic outcomes.

First-Line Enzalutamide May Confer a Survival Benefit for Metastatic Castration-Resistant Prostate Cancer

First-Line Enzalutamide May Confer a Survival Benefit for Metastatic Castration-Resistant Prostate Cancer

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Patients may benefit from earlier lines of enzalutamide for the treatment of metastatic castration-resistant prostate cancer.

Active Surveillance May Be a Good Option for Younger Men with Prostate Cancer

Active Surveillance May Be a Good Option for Younger Men with Prostate Cancer

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The effect of age on outcomes in active surveillance is not well reported and requires further study.

Certain Renal Cancer Subtypes Linked to Obesity

Certain Renal Cancer Subtypes Linked to Obesity

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Obesity is associated with an increased likelihood of clear cell and possibly chromophobe renal cell carcinoma.

Bladder Cancer Survival Better Among Married Patients

Bladder Cancer Survival Better Among Married Patients

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Widowed patients with bladder urothelial carcinoma have the worst 5-year cancer-specific survival rates among unmarried patients.

Beverages Sweetened With Added Sugars May Increase the Risk of Prostate Cancer

Beverages Sweetened With Added Sugars May Increase the Risk of Prostate Cancer

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Some prior evidence has linked increased sugar consumption to cancer development, but its impact on prostate cancer is unknown.

Increased Body Mass Index May Be Predictive of Recurrence, Progression in Bladder Cancer

Increased Body Mass Index May Be Predictive of Recurrence, Progression in Bladder Cancer

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Evidence for the impact of obesity on outcomes for bladder cancer have been conflicting and require further study.

Triclosan and Cancer Risk: Is There a Link?

Triclosan and Cancer Risk: Is There a Link?

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Some studies suggest triclosan could have oncogenic properties, but more research is needed to confirm a causal link.

FDA Approves Enzalutamide for Nonmetastatic Castration-Resistant Prostate Cancer

FDA Approves Enzalutamide for Nonmetastatic Castration-Resistant Prostate Cancer

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This latest approval now makes enzalutamide the only FDA-approved oral medication indicated for both metastatic and nonmetastatic castration-resistant prostate cancer.

Is Genomic Medicine Failing Minority Patients?

Is Genomic Medicine Failing Minority Patients?

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Racial minorities are poorly represented in genomic research databases, raising important questions about whether or not all patients will benefit equally from advances in precision oncology.

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